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5-Amino-1-methylquinolinium iodide is the lead first-in-class small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) an enzyme overexpressed in white adipose tissue of obese individuals where it consumes the methyl-donor pool and depletes tissue NAD

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Amsterdam, Netherlands: European Medicines Agency, 183226

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[103] [100] [104] Several other applications to sell generic versions have been made, but not yet approved, including by Aspen Pharmacare, Sandoz, Taro Pharmaceuticals and Teva Pharmaceuticals